The Author(s), under exclusive licence to Springer Nature Limited. Our data suggest that GP73 is a glucogenic hormone that likely contributes to SARS-CoV-2-induced abnormalities in systemic glucose metabolism. In patients with COVID-19, plasma GP73 levels are elevated and positively correlate with blood glucose levels. GP73 blockade with an antibody inhibits excessive glucogenesis stimulated by SARS-CoV-2 in vitro and lowers elevated fasting blood glucose levels in infected mice. Share sensitive information only on official, secure websites. We further show that GP73 secretion is increased in cultured cells infected with SARS-CoV-2, after overexpression of SARS-CoV-2 nucleocapsid and spike proteins and in lungs and livers of mice infected with a mouse-adapted SARS-CoV-2 strain. /f5Bjournalfacet5D5B5DJournal+of+colloid+and+interface+science&f5Bpublicationyearrev5D5B5D7978-2022&f5Bsubjectfacet5D5B5Dsorption+isotherms&f5Bsubjectfacet5D5B5Dwater+pollution&sorttitleĚ locked padlock) or means you’ve safely connected to the. It originated from the nobility system of the Qing Dynasty and has more favorable treatment and privileges than ordinary princes. The iron hat king is a hereditary and irreplaceable king. We first demonstrate that GP73 secretion is induced in multiple tissues upon fasting and that GP73 stimulates hepatic gluconeogenesis through the cAMP/PKA signaling pathway. Yixin and Yizhen grew up together under the care of Concubine Jing, and they are of the same age, just like brothers. Here, we connect the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection. However, the molecular mechanisms for how SARS-CoV-2 infection alters glycometabolic control are incompletely understood. Economics Yuxuan Mu Graduate Student - MAE. On July 2, 2021, the German Joint Science Conference (Gemeinsame Wissenschaftskonferenz, GWK) decided to fund the National Research Data Infrastructure (NFDI) consortium for Data Science and Artificial Intelligence (NFDI4DataScience) with an amount in the double-digit millions over a duration of five years.Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. : Schloss Dagstuhl becomes part of the National Research Data Infrastructure for Data Science and Artificial Intelligence During this time, she worked at international law firms in Munich and Shanghai. ![]() ![]() Prior to joining the Firm as an associate in 2020, she served her legal traineeship at the Higher Regional Court of Munich. This includes the opportunity to qualify yourself for a doctorate in the context of the challenges arising from managing and operating a semantic Yixin Yang is member of Baker McKenzies Corporate/Mergers and Acquisitions Practice Group in Frankfurt. Interested in working on the world’s most comprehensive open indexing service in computer science? We are currently looking for three additional members to join the dblp team. Yuntao Chen, UCL Nina Hemmings, Nuffield Trust Yuyang Liu, SYSU Yun Huang, SYSU Yanjuan Wu, SYSU Yixin Li, UCL. The response exceeded our expectations: We received the amazingly high number of 1046 : Results and learnings from the dblp User Survey 2020/2021 įrom December 2020 to January 2021, we asked you to participate in an online survey in order to help us understand how researchers are using dblp, and how dblp and its features are perceived by the public. These dump files have always been in high demand over the years (with 500+ downloads in February 2022 alone) and are used as For more than 20 years, a full dump of all dblp records in our own XML format has been available as open data for download and reuse.
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